O Combo Volcanic NeuroBalance é composto pelo Volcanic NeuroBalance ASD® e o Volcanic NeuroBalance Melatonin®, confira:

Volcanic NeuroBalance ASD® – Inovação para o Suporte ao TEA

O Volcanic NeuroBalance ASD® é um suplemento revolucionário, desenvolvido com base na ciência para oferecer suporte natural e eficaz para pessoas  com Transtorno do Espectro Autista (TEA). Com a crescente prevalência do TEA e opções farmacêuticas limitadas, após 2 anos de pesquisa, essa fórmula inovadora chega como uma alternativa segura e cientificamente respaldada com suplementos que podem ajudar a melhorar sintomas associados ao desenvolvimento cognitivo, comunicação e comportamento.

Ciência e Tecnologia para uma Vida Melhor

Cada ingrediente do Volcanic NeuroBalance ASD® foi criteriosamente selecionado com base em evidências científicas abaixo listadas, que demonstram benefícios diretos para indivíduos com TEA:

• - PEA – Palmitoiletanolamida: Reduz a irritabilidade e a agressividade, ajudando no equilíbrio emocional.
• - Vitamina D: Essencial para o desenvolvimento cognitivo e elevação da serotonina, influencia positivamente no humor e no comportamento social.
• - Coenzima Q10: Contribui para clareza mental, cognição e interação social, auxilia no aprimoramento da comunicação verbal.
• - Trans-Resveratrol:  Atua como anti-inflamatório natural, contribui para a redução da hiperatividade e a melhora do comportamento.
• - Antocianinas de sementes de uva: Poderoso antioxidante com efeito imunomodulador, que contribui para o desenvolvimento da fala e a melhora na comunicação.

Público:

• - Indivíduos com TEA que necessitam de suporte nutricional para promover equilíbrio emocional, neuroproteção e melhora na interação social.
• - Indivíduos com hipersensibilidade sensorial e desafios na regulação emocional, que podem se beneficiar de ingredientes que auxiliam na estabilidade do humor.
• - Pessoas com dificuldades de comunicação verbal que buscam suporte nutricional para otimizar a função neurológica e promover o desenvolvimento da fala.

Orientações de Uso do Volcanic NeuroBalance ASD®:

• - Adicionar 2g (1/2 (meia) medida dosadora) sobre a comida ou bebida e misturar.
• - Consumir 1 vez ao dia ou conforme orientação do seu médico ou nutricionista.

Volcanic NeuroBalance Melatonin® – Sono de Qualidade e Muito Mais

O sono é essencial para a regulação emocional, o desenvolvimento cognitivo e a qualidade de vida. Para indivíduos com Transtorno do Espectro Autista (TEA), os desafios para dormir bem podem impactar diretamente o humor, o comportamento e o bem-estar geral. O Volcanic NeuroBalance Melatonin® foi desenvolvido para oferecer um suporte seguro, ajudar a regular o ciclo do sono e promover noites mais tranquilas e restauradoras.

Muito Além da Melatonina – Benefícios Comprovados para o TEA

Mais do que apenas um regulador do sono, a melatonina desempenha um papel fundamental na saúde neurológica e metabólica. Sua ação vai além da indução ao descanso, trazendo benefícios essenciais para indivíduos com TEA:

• - Sono Profundo e Restaurador: Regula o ciclo sono-vigília, reduz despertares noturnos e promove um descanso mais reparador.
• - Redução do Estresse Oxidativo e Inflamação: Atua como um antioxidante poderoso, combate processos inflamatórios comuns no TEA e protege as células cerebrais.
• - Equilíbrio dos Neurotransmissores: Auxilia na modulação de neurotransmissores, promove maior estabilidade emocional, regulação do humor e comportamento mais equilibrado.
• - Suporte ao Eixo Intestino-Cérebro: Melhora a saúde intestinal, essencial para um equilíbrio neuroquímico saudável e bem-estar geral.

Público:

• - Pessoas com Transtorno do Espectro Autista (TEA) que apresentam dificuldades para adormecer ou manter um sono contínuo.
• - Pessoas com transtornos do sono ou dificuldades para dormir, que precisam de um suplemento natural para regular o ritmo circadiano.
• - Indivíduos expostos frequentemente à luz azul das telas de celulares, computadores e dispositivos eletrônicos que buscam melhorar a qualidade do sono.
• - Pessoas com rotinas irregulares de sono, como profissionais que trabalham em turnos alternados ou viajantes frequentes que sofrem com jet lag.

Orientações de Uso do Volcanic NeuroBalance Melatonin®:

• - Pingue 1 gota à noite debaixo da língua, 1 a 2 horas antes de ir dormir.
• - Agite antes de usar.

Referências Bibliográficas Volcanic NeuroBalance ASD®:

• Tordjman S. et al. Melatonin: Pharmacology, Functions and Therapeutic Benefits. Curr Neuropharmacol. 2017 Apr;15(3):434-443.  2. Zhou-yue Wu et al. Autism spectrum disorder (ASD): Disturbance of the melatonin system and its implications. Biomed Pharmacother. 2020 Oct; 130:110496. 
• Mei  Xiong et al. Efficacy of Melatonin for Insomnia in Children with Autism Spectrum Disorder: A Meta-analysis. Neuropediatrics. 2023 Jun; 54(3):167-173.  2.  Souders M C et al. Sleep in children with autism spectrum disorder. Curr Psychiatry Rep. 2017;19(06):34. 3. Moore M. et al. Assessment of sleep in children with autism spectrum disorder. Children (Basel). 2017 Aug 8;4(8):72.
• Melatonin Versus Placebo in Children with Autism Spectrum Conditions and Severe Sleep Problems Not Amenable to Behaviour Management Strategies: A Randomised Controlled Crossover Trial
• . Wright B, Sims D, Smart S, et al. Melatonin versus placebo in children with autism spectrum conditions and severe sleep problems not amenable to behaviour management strategies: a randomised controlled crossover trial. J Autism Dev Disord. 2011 Feb;41(2):175-84.
• Wright B, Sims D, Smart S, et al. Melatonin versus placebo in children with autism spectrum conditions and severe sleep problems not amenable to behaviour management strategies: a randomised controlled crossover trial. J Autism Dev Disord. 2011 Feb;41(2):175-84.
• Long-term melatonin treatment for the sleep problems and aberrant behaviors of children with neurodevelopmental disorders. Kotaro Yuge, Shinichiro Nagamitsu, Yuko Ishikawa, Izumi Hamada, Hiroyuki Takahashi, Hideyuki Sugioka, Osamu Yotsuya, Kazuo Mishima, Masaharu Hayashi & Yushiro Yamashita
• Long-Term Efficacy and Safety of Pediatric Prolonged-Release Melatonin for Insomnia in Children with Autism Spectrum Disorder. Athanasios Maras, Carmen M. Schroder, Beth A. Malow, Robert L. Findling, John Breddy, Tali Nir, Shiri Shahmoon, Nava Zisapel, and Paul Gringras
• Pediatric Prolonged-Release Melatonin for Sleep in Children with Autism Spectrum Disorder: Impact on Child Behavior and Caregiver’s Quality of Life. Carmen M. Schroder, Beth A. Malow, Athanasios Maras, Raun D. Melmed, Robert L. Findling, John Breddy, Tali Nir, Shiri Shahmoon, Nava Zisapel & Paul Gringras
• Yuge K, Nagamitsu S, Ishikawa Y, et al. Long-term melatonin treatment for the sleep problems and aberrant behaviors of children with neurodevelopmental disorders. BMC Psychiatry. 2020 Sep 10;20(1):445.
• Maras A, Schroder CM, Malow BA, et al. Long-Term Efficacy and Safety of Pediatric Prolonged-Release Melatonin for Insomnia in Children with Autism Spectrum Disorder. J Child Adolesc Psychopharmacol. 2018 Dec;28(10):699-710.
• Schroder CM, Malow BA, Maras A, et al. Pediatric Prolonged-Release Melatonin for Sleep in Children with Autism Spectrum Disorder: Impact on Child Behavior and Caregiver's Quality of Life. J Autism Dev Disord. 2019 Aug;49(8):3218-3230.
•  Menegas S, et al. Potential mechanisms of action of resveratrol in prevention and therapy for mental disorders. J Nutr Biochem. 2023 Nov;121:109435.
• Resveratrol as adjunctive therapy in treatment of irritability in children with autism: A double-blind and placebo-controlled randomized trial. Fatemeh Hendouei, Hossein Sanjari Moghaddam, Mohammad Reza Mohammadi, Negin Taslimi, Farzin Rezaei, Shahin Akhondzadeh
• Hendouei F, et al. Resveratrol as adjunctive therapy in treatment of irritability in children with autism: A double-blind and placebo-controlled randomized trial. J Clin Pharm Ther. 2020 Apr;45(2):324-334.
• Hendouei F, et al. Resveratrol as adjunctive therapy in treatment of irritability in children with autism: A double-blind and placebo-controlled randomized trial. J Clin Pharm Ther. 2020 Apr;45(2):324-334.
• Resveratrol Treatment of Autism Spectrum Disorder – A Pilot Study. Marchezan, Josemar PhD; Deckmann, Iohanna PhD; da Fonseca, Guilherme Cordenonsi PhD; Margis, Rogerio PhD; Riesgo, Rudimar PhD; Gottfried, Carmem PhD
• Marchezan J, Deckmann I, da Fonseca GC, Margis R, Riesgo R, Gottfried C. Resveratrol Treatment of Autism Spectrum Disorder-A Pilot Study. Clin Neuropharmacol. 2022 Sep-Oct 01;45(5):122-127.
• Marchezan J, Deckmann I, da Fonseca GC, Margis R, Riesgo R, Gottfried C. Resveratrol Treatment of Autism Spectrum Disorder-A Pilot Study. Clin Neuropharmacol. 2022 Sep-Oct 01;45(5):122-127.
• Cirilli I, et al. Role of Coenzyme Q10 in Health and Disease: An Update on the Last 10 Years (2010-2020). Antioxidants (Basel). 2021 Aug 23;10(8):1325.
• Ebrahimi A, et al. Involvement of Coenzyme Q10 in Various Neurodegenerative and Psychiatric Diseases. Biochem Res Int. 2023 Nov 1;2023:5510874.
• Bagheri S, et al. Neuroprotective effects of coenzyme Q10 on neurological diseases: a review article. Front Neurosci. 2023 Jun 23;17:1188839.
• Coenzyme Q10 supplementation reduces oxidative stress and decreases antioxidant enzyme activity in children with autism spectrum disorders. Mousavinejad E, Ghaffari MA, Riahi F, Hajmohammadi M, Tiznobeyk Z, Mousavinejad M
•  Mousavinejad E, et al. Coenzyme Q10 supplementation reduces oxidative stress and decreases antioxidant enzyme activity in children with autism spectrum disorders. Psychiatry Res. 2018 Jul;265:62-69.
• Coenzyme Q10 supplementation reduces oxidative stress and decreases antioxidant enzyme activity in children with autism spectrum disorders. Elham Mousavinejad, Mohammad Ali Ghaffari, Forough Riahi, Maryam Hajmohammadi, Zeinab Tiznobeyk e Masoumeh Mousavinejad 
• Gvozdjáková A et al. Ubiquinol improves symptoms in children with autism. Oxid Med Cell Longev. 2014;2014:798957.
• Clayton, P.; Hill, M.; Subah, S.; Venkatesh, R. Palmitoiletanolamida: Um composto natural para gestão da saúde. Int. J. Mol. Sci. 2021 , 22;
• Herrera MI, et al. Palmitoylethanolamide attenuates neurodevelopmental delay and early hippocampal damage following perinatal asphyxia in rats. Front Behav Neurosci. 2022 Aug 25;16:953157. doi: 10.3389/fnbeh.2022.953157. Erratum in: Front Behav Neurosci. 2022 Dec 19;16:1115398.  
• Palmitoylethanolamide as adjunctive therapy for autism: Efficacy and safety results from a randomized controlled trial. Khalaj, M., Saghazadeh, A., Shirazi, E., Shaibafan, M. R., Alavi, K., Shooshari, M. H.,  & Akhondzadeh, S.
• Khalaj M, Saghazadeh A, Shirazi E, et al. Palmitoylethanolamide as adjunctive therapy for autism: Efficacy and safety results from a randomized controlled trial. J Psychiatr Res. 2018 Aug;103:104-111.
• Beneficial Effects of Palmitoylethanolamide on Expressive Language, Cognition, and Behaviors in Autism: A Report of Two Cases. Nicola Antonucci, Alessandra Cirillo, Dario Siniscalco
• Antonucci et al. Beneficial effects of palmitoylethanolamide on expressive language, cognition, and behaviors in autism: a report of two cases. Case reports in psychiatry, v. 2015, n. 1, p. 325061, 2015.
• Antonucci et al. Beneficial effects of palmitoylethanolamide on expressive language, cognition, and behaviors in autism: a report of two cases. Case reports in psychiatry, v. 2015, n. 1, p. 325061, 2015.
• Palmitoylethanolamide as adjunctive therapy for autism: Efficacy and safety results from a randomized controlled trial. Mona Khalaja, Amene Saghazadehb, Elham Shirazia, Mohammad-Reza Shalbafana, Kaveh Alavia, Mitera Hakim Shooshtaria, Fatemeh Yousefi Laksaria, Maryamalsadat Hosseinia, Mohammad-Reza Mohammadib e Shahin Akhondzadeh (2018)
• Khalaj, Mona et al. Palmitoylethanolamide as adjunctive therapy for autism: Efficacy and safety results from a randomized controlled trial. Journal of psychiatric research, v. 103, p. 104-111, 2018. 
• KHALAJ, Mona et al. Palmitoylethanolamide as adjunctive therapy for autism: Efficacy and safety results from a randomized controlled trial. Journal of psychiatric research, v. 103, p. 104-111, 2018.
• Panchal, S.K.; Brown, L. Potential Benefits of Anthocyanins in Chronic Disorders of the Central Nervous System. Molecules 2023, 28, 80.
• Attenuation of Autism-like Behaviors by an Anthocyanin-Rich Extract from Portuguese Blueberries via Microbiota–Gut–Brain Axis Modulation in a Valproic Acid Mouse Model. Diana Serra, Joana F. Henriques, Fábio J. Sousa, Mariana Laranjo, Rosa Resende, Marisa Ferreira-Marques , Victor de Freitas, Gabriela Silva, João Peça, Teresa C. P. Dinis  e Leonor M. Almeida.
• Serra D, Henriques JF, Sousa FJ, Laranjo M,, et al. Attenuation of Autism-like Behaviors by an Anthocyanin-Rich Extract from Portuguese Blueberries via Microbiota–Gut–Brain Axis Modulation in a Valproic Acid Mouse Model. International Journal of Molecular Sciences. 2022; 23(16):9259.
• 9259. Serra D, Henriques JF, Sousa FJ, Laranjo M,, et al. Attenuation of Autism-like Behaviors by an Anthocyanin-Rich Extract from Portuguese Blueberries via Microbiota–Gut–Brain Axis Modulation in a Valproic Acid Mouse Model. International Journal of Molecular Sciences. 2022; 23(16):
• Serra D, Henriques JF, Sousa FJ, Laranjo M,, et al. Attenuation of Autism-like Behaviors by an Anthocyanin-Rich Extract from Portuguese Blueberries via Microbiota–Gut–Brain Axis Modulation in a Valproic Acid Mouse Model. International Journal of Molecular Sciences. 2022; 23(16)
• A Randomised Placebo-Controlled Study of Purified Anthocyanins on Cognition in Individuals at Increased Risk for Dementia. Dag Aarsland, Khadija Khalifa, Anne K Bergland, Hogne Soennesyn, Ketil Oppedal, Lise B A Holteng, Ragnhild Oesterhus, Arne Nakling, Jonas A Jarholm,  Chiara de Lucia, Tormod Fladby, Helen Brooker, Ingvild Dalen, Clive Ballard.
• Wild blueberry (poly)phenols can improve vascular function and cognitive performance in healthy older individuals: a double-blind randomized controlled trial. Eleanor Wood, Sabine Hein, Robin Mesnage, Filipe Fernandes, Nimaya Abhayaratne, Yifan Xu, Zicheng Zhang, Lynne Bell, Claire Williams, Ana Rodriguez-Mateos.
• A Randomized, Crossover Study of the Acute Cognitive and Cerebral Blood Flow Effects of Phenolic, Nitrate and Botanical Beverages in Young, Healthy Humans. Philippa A Jackson, Emma L Wightman, Rachel Veasey, Joanne Forster, Julie Khan, Caroline Saunders, Siobhan Mitchell, Crystal F Haskell-Ramsay, David O Kennedy
• Aarsland D et al. A Randomised Placebo-Controlled Study of Purified Anthocyanins on Cognition in Individuals at Increased Risk for Dementia. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 31(2), 141–151.
• Eleanor et al. Wild blueberry (poly) phenols can improve vascular function and cognitive performance in healthy older individuals: a double-blind randomized controlled trial. The American journal of clinical nutrition, v. 117, n. 6, p. 1306-1319, 2023.
• Jackson PA, et al. A Randomized, Crossover Study of the Acute Cognitive and Cerebral Blood Flow Effects of Phenolic, Nitrate and Botanical Beverages in Young, Healthy Humans. Nutrients. 2020 Jul 28;12(8):2254
• Wimalawansa SJ. Vitamin D Deficiency: Effects on Oxidative Stress, Epigenetics, Gene Regulation, and Aging. Biology (Basel). 2019 May 11;8(2):30.
• Clinical improvement following vitamin D3 supplementation in Autism Spectrum Disorder. Junyan Feng, Ling Shan, Lin Du, Bing Wang, Honghua Li, Wei Wang, Tiantian Wang, Hanyu Dong, Xiaojing Yue, Zhida Xu, Wouter G. Staal, Feiyong Jia
• Feng J, et al. Clinical improvement following vitamin D3 supplementation in Autism Spectrum Disorder. Nutr Neurosci. 2017 Jun;20(5):284-290.

Referências Bibliográficas Volcanic NeuroBalance Melatonin®:

• Tordjman S. et al. Melatonin: Pharmacology, Functions and Therapeutic Benefits. Curr Neuropharmacol. 2017 Apr;15(3):434-443.  2. Zhou-yue Wu et al. Autism spectrum disorder (ASD): Disturbance of the melatonin system and its implications. Biomed Pharmacother. 2020 Oct; 130:110496.
• Mei  Xiong et al. Efficacy of Melatonin for Insomnia in Children with Autism Spectrum Disorder: A Meta-analysis. Neuropediatrics. 2023 Jun; 54(3):167-173.  2.  Souders M C et al. Sleep in children with autism spectrum disorder. Curr Psychiatry Rep. 2017;19(06):34. 3. Moore M. et al. Assessment of sleep in children with autism spectrum disorder. Children (Basel). 2017 Aug 8;4(8):72.
• Melatonin Versus Placebo in Children with Autism Spectrum Conditions and Severe Sleep Problems Not Amenable to Behaviour Management Strategies: A Randomised Controlled Crossover Trial. Melatonin Versus Placebo in Children with Autism Spectrum Conditions and Severe Sleep Problems Not Amenable to Behaviour Management Strategies: A Randomised Controlled Crossover Trial